PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON THE LEAVES OF TECOMA MOLLIS HUMB. AND BONPL CULTIVATED IN EGYPT

Document Type : Original Article

Authors

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

a-Amyrin (1), 3-b-hydroxy-urs-12-ene-28-aldehyde (2) b-sitosterol (3), ursolic acid lactone (4), ursolic acid (5), 2-b,3-b,19-a-trihydroxy-urs-12-ene-28-oic acid (2-tormentic acid) (6), b-sitosterol-3-O-b-D-glucoside (7) apigenin-7-O-a-L-rhamnoside (8), apigenin-7-O-rutinoside (9), luteolin-7-O-rutinoside (10) and apigenin-6,8-di-C-b-D-glucopyranoside (Vicenin 2) (11) were isolated for the first time from the ethanolic extract of the leaves of Tecoma mollis Humb and Bonpl. cultivated in Egypt. Identification of these compounds has been established by physical and spectral data (UV, IR, MS, 1H- and 13C-NMR) as well as by comparison with authentic samples. Moreover, the biological screening showed that the non-polar fraction of the alcoholic extract (n-hexane, chloroform), polar fraction (ethyl acetate, n-butanol) and aqueous extract as well as ursolic acid possess significant anti-inflammatory, analgesic and antipyretic activities. In addition, the polar fraction and aqueous extract possess also a significant anticonvulsant activity.