Present work was aimed to develop a liquid in-situ raft forming floating gastroretentive system of repaglinide using gellan gum, pectin, and sodium alginate. The formulations were characterized in terms of compatibility of drug-excipient by Fourier transform infrared, drug content, effect of processing parameters on physical form of drug (crystalline or amorphous) by X-ray diffraction analysis, thermal behaviour by differential scanning calorimetry, and in-vitro drug release study. The results confirm no interaction between the drug-excipients and fusion of drug crystals within the polymer matrix in amorphous form. The gel raft-floated for more than 24 hrs.. All the formulations showed instantaneous gelation within 30 seconds in 0.1 N HCl (pH 1.2). Formulation containing gellan gum (500 mg), pectin (500 mg), and glycerol monostearate (500 mg) released 21% of the drug in first 4 hrs., 69% in 6 hrs. and reached 97% in 7 hrs. Without gellan gum, 35% of the drug was released in the first 2 hrs. and reached 90% in 4 hrs. Based on these results it is suggested that the incorporation of drug into the liquid in-situ raft forming floating system may be an appropriate strategy to improve the dissolution profile of poorly soluble drugs.
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