Document Type : Original Article
Authors
1
School of Clinical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia
2
Chronic Respiratory Diseases Research Centre (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences
3
Department of Medical Affairs, Abidi Pharmaceuticals, Tehran, Iran
4
Neuroscience Interdepartmental Program, University of California, Los Angeles, California, USA
5
American Career College, California, USA
6
Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Desloratadine is a relatively new, second-generation, tricyclic antihistamine which came
into medical use in 2001. This study aimed to review the available evidence in the literature
around the clinical efficacy of desloratadine on a range of allergic conditions. A database
search in Medline, PubMed, Embase, and Google Scholar was conducted for the research
articles published until July 2020, using the keyword desloratadine. An additional reference
lists search and citation tracking were also performed. Research articles in English pertaining
to desloratadine and its efficacy were considered for inclusion. Study designs, including
randomized controlled trials (RCT), observational/case-control studies, and case series were
considered. The collective evidence from the current literature shows superior efficacy of
desloratadine compared to placebo and some of the other treatment options in the management
of seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR), chronic idiopathic
urticaria (CIU), and asthmatic symptoms. There is also evidence for potential new roles
introduced for desloratadine such as acne treatment, chronic otitis media, and chronic
rhinosinusitis, which warrants further investigation. In most studies, desloratadine’s safety and
tolerability were comparable with placebo. Current evidence suggest that desloratadine is an
ideal option for most of the allergic conditions due to its efficacy as well as favourable safety
and tolerability profile. Further large-scale studies are needed to establish the efficacy and
safety profile of desloratadine and to compare its effectiveness against other treatments in the
management of allergic conditions.
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