Document Type : Original Article
Authors
1
Forensic Medicine Authority, Ministry of Justice, Egypt.
2
Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
3
Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
4
Department of internal Medicine, College of Medicine, University of Cincinati, Cincinati, OH 45267-0595, USA.
5
Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abstract
The etiology of inflammatory and autoimmune diseases is complex and not yet fully
understood. Their pathogenesis includes mechanisms in which both innate and adaptive
immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells
expressing an invariant TCRα chain (Vα7.2-Jα33 in human and Vα19-Jα33 in mice) and
recognize the conserved MHC-I-related molecule MR1, which presents bacterial metabolites
derived from the synthesis of vitamin B. Although most of the studies support a hazardous role
of MAIT cells in tissue inflammation and destruction, few studies suggest a protective role.
MAIT cells have tissue homing properties with the production of inflammatory cytokines,
signifying that they may play an essential role in autoimmune and inflammatory diseases. In the
current study, we clarified the present knowledge on MAIT cells in systemic lupus
erythematosus.
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