RENOPROTECTIVE EFFECT OF TAXIFOLIN AND/OR VITAMIN C ON DIAZINON-INDUCED RENAL INJURY IN RATS

Document Type : Original Article

Authors

1 Basrah Health Directory, Iraq

2 Department of Pharmacology and Toxicology, Pharmacy College, Basrah University, Iraq

Abstract

Insecticides have come to be used in a wrong way and uncontrollably, leading to an
increase in the incidence of chronic diseases such as chronic nephropathies, diabetes, and other
metabolic disorders. Objective: To evaluate the protective effect of Taxifolin and/or vitamin C
against Diazinon-induced renal dysfunction. Methods: Thirty-six female rats were divided into
six groups gavaged orally for 30 days. Group 1 received 20 mg/kg DZN. Group 2 received 25
mg/kg Taxifolin, 100 mg/kg vitamin C, and then 20 mg/kg DZN. Group 3 received 25 mg/kg
Taxifolin and then 20 mg/kg DZN. Group 4 received 100 mg/kg vitamin C and then 20 mg/kg
DZN. Group 5 received 25 mg/kg Taxifolin and then 100 mg/kg vitamin C. Finally, group 6
received distilled water. In the end, the rats were sacrificed and their blood and kidneys were
collected for biochemical analysis and histopathology. Conclusion: Sub-acute administration of
Taxifolin and vitamin C provides a renoprotective effect against oxidative stress induced by
DZN.
Bulletin of Pharmaceutical Sciences Assiut University
Volume 44, Issue 2
December 2021
Pages 647-656

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