THE EFFECT OF TABLET GEOMETRY ON TRAMADOL HYDROCHLORIDE RELEASE FROM MATRIX SYSTEMS

Document Type : Original Article

Authors

1 Deptartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Tishreen University, Lattakia city, Syria

2 Deptartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Aleppo University, Aleppo city, syria

3 Deptartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Tishreen University, Lattakia city, Syria.

Abstract

The objective of this study was to explore the effect of geometry and tablet design on release pattern of tramadol hydrochloride as a model of freely soluble drug from matrix systems. Hydrophilic and hydrophobic matrices were prepared by direct compression method using HPMC with two different molecular weight and Kollidon® SR as a release-retarding agent respectively at drug: polymer ratio (1:5) for each excipient, in distinct strengths and geometries (i.e. shape, size and dimensions) at parallel and differing surface area to volume ratios. It was found that tramadol release from manufactured tablets is similar when the surface area to volume ratio is equal, regardless of the type of matrix former, drug strength, tablet design. Per contra, the tablet with smaller surface area to volume values had the slower release rate among the same shape. Thus, tablet geometry supplies additional versatility for these systems, making formulators to achieve the desired release characteristics for their drug of option.

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