NEUROPHARMACOLOGICAL ACTIVITIES OF METHANOLIC EXTRACT OF LEAVES OF VISCUM CAPITELLATUM SMITH.

Document Type : Original Article

Authors

1 Department of Pharmacognosy, MES College of Pharmacy, Sonai, Ahmednagar, India

2 Department of Pharmacognosy, SVPM'S College of Pharmacy, Malegaon(BK), Pune, India

3 Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule India

Abstract

In present study, Viscum capitellatum Sm., hyperparasite was investigated for various neuropharmacological activities such as locomotor activity, skeletal muscle relaxation activity, antianxiety and sleep potentiation using Swiss Albino mice. The effects of methanol extract of V. capitellatum (MEVC)on anxiety, depression, rota rod performance and pentobarbital-induced sleep time were evaluated. The anxiolytic activity of MEVC at lower dose (100 mg/kg) was characterized by increased time spent and number of entries in open arms in the elevated plus maze paradigm as compared to control group. The MEVC (100, 200, and 400 mg/kg, i.p.) showed dose-dependent significant increase in motor coordination in rota rod performance test. The MEVC at the doses 500 mg/kg, i.p. was found to produce a significant prolongation of pentobarbital-induced sleeping time. The phytochemical estimation revealed the presence of significantly high amount of polyphenols. The results of the study showed that the V. capitellatum possesses neuropharmacological activity, confirming the traditional claims.

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