T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY

Abdel-moneam, Yasmien H.; Abdel-Rahim, Mona H.; Hetta, Helal F.; Herdan, Omar M.; Hassanein, Khalid M.

doi:10.21608/bfsa.2022.239581

T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY

Document Type : Original Article

Authors

¹ Department of Microbiology & Immunology, Faculty of Pharmacy, Assuit University, Assuit, Egypt

² Department of Microbiology & Immunology, Faculty of Medicine, Assuit University, Assuit, Egypt

³ Department of Internal Medicine, Faculty of Medicine, Assuit University, Assuit, Egypt

10.21608/bfsa.2022.239581

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder distinguished by the presence of autoantibodies causing multiorgan damages. Follicular regulatory T (Tfr) cells are mainly located in germinal centers (GCs) and play vital role in inducing Tfh suppression, sustaining B cell tolerance and inhibiting autoantibodies development. Dysregulated Tfr cells result in abnormal GCs responses and contribute to the pathogenesis of autoimmune diseases. However, the exact role of Tfr cells in SLE is still ambiguous. The present review focuses on the immunological bases and the disturbed balance of Tfr and Tfh cells in autoimmune diseases, particularly SLE. In addition to the new therapeutic strategies for SLE.

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