PHYTOCHEMICAL SCREENING AND PHARMAOCOLOGICAL EVALUATION OF TECOMA GAUDICHAUDI

Veeramaneni, Alekhya; Deepan, T.; Ganapaty, S.

doi:10.21608/bfsa.2022.271489

PHYTOCHEMICAL SCREENING AND PHARMAOCOLOGICAL EVALUATION OF TECOMA GAUDICHAUDI

Document Type : Original Article

Authors

¹ Department of Pharmacognosy GIET School of Pharmacy Rajahmundry

² Department of Pharmacognosy, GIET School of Pharmacy, NH-16, Chaitanya knowledge city, Rajamahendravaram-533296, Andhrapradesh, India

³ Department of Pharmacognosy, GITAM Institute of Pharmacy, Gandhinagar, Rushikonda, Visakhapatnam-530045, Andhrapradesh, India

10.21608/bfsa.2022.271489

Abstract

Tecoma gaudichaudi is a tropical flowering plant in the Bignoniaceae family that is used to treat diabetes. The aim of this research was to evaluate antioxidant, anti-inflammatory, and antibacterial properties. Tecoma gaudichaudi ethanolic extract had considerable antioxidant activity. Antioxidant activity was measured using the DPPH assay, the radical scavenging method, and the superoxide assay. Antibacterial activity and antifungal activity were performed by cup plate method by using Ciprofloxacin as standard for antibacterial and antifungal activity. Ethanolic extract of Tecomo gaudichaudi shows significant antibacterial effect against S. Aureus, B. Subtilis, P. vulgaris and E. coli using ciprofloxacin (50µg/ml) as standard. Three alternative methods were used to calculate IC₅₀ values for antioxidant activity. The IC₅₀ values for T. gaudichaudi (21 g/ml) and ascorbic acid (12 g/ml) were obtained using the DPPH technique. For anti-inflammatory studies the extracts show remarkable zone of inhibition ranging from 58.97 to 72.35 µg/ml respectively compared to standard indomethacin. Steroids, saponins, flavonoids, triterpenes, and phenols are found in preliminary phytochemical investigation. In conclusion, ethanolic extract of Tecomo gaudichaudi shows significant antioxidant, anti-inflammatory and antibacterial properties.

Keywords