Document Type : Original Article
Authors
1
Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia
2
Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia- Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
3
Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia-Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Abstract
The present study analyzed the chemical composition and evaluated the cytotoxicity of essential oil extracted from Decaspermum parviflorum (Lam.) A.J.Scott (Myrtaceae). The chemical composition of the essential oil was analyzed using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Thirty-five components were identified, accounting for 97.3% and comprising mainly of monoterpene hydrocarbons, 52.5%. α-Pinene (40.5%), β-pinene (9.2%), β-eudesmol (8.0%), globulol (7.5%), and β-caryophyllene (5.1%) were identified as its major components. The oil exhibits potent cytotoxicity (IC50 values of 68.5-70.2 μg/mL) against three human cancer cell lines; HepG2 (liver), MCF7 (breast), and A549 (lung). This is the first report on the chemical composition and cytotoxicity of D. parviflorum essential oil from the context of Malaysia in this study. The present study highlights the potential of using essential oil as an excellent alternative for the development of anticancer chemotherapeutic agents for the pharmaceutical industry
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