PREVALENCE OF ANTIBIOTICS RESISTANCE AMONG PATIENTS UNDERGOING BRONCHOSCOPY IN CHEST DEPARTMENT AT AL-SHIFA MEDICAL COMPLEX IN GAZA STRIP, PALESTINE

Taleb, Mahmoud Hussien; Elkhair, Emad Abou; Timraz, Rolla Abed; El Bilbeisi, Abdel Hamid Hassan

doi:10.21608/bfsa.2022.271645

PREVALENCE OF ANTIBIOTICS RESISTANCE AMONG PATIENTS UNDERGOING BRONCHOSCOPY IN CHEST DEPARTMENT AT AL-SHIFA MEDICAL COMPLEX IN GAZA STRIP, PALESTINE

Document Type : Original Article

Authors

¹ Department of Pharmacology and Medical Sciences, Faculty of Pharmacy, Al Azhar University of Gaza, Palestine

² Department of Biology, Faculty of Science, Al-Azhar University-Gaza, Palestine

³ Ministry of Health, Gaza, Palestine

⁴ Department of Nutrition, School of Medicine and Health Sciences, University of Palestine, Gaza Strip, Palestine

10.21608/bfsa.2022.271645

Abstract

Background: This study was conducted to determine the prevalence of antibiotics resistance among patients undergoing bronchoscopy in Chest Department at Al-Shifa Medical Complex. Method: This cross-sectional study was conducted in year 2021. A total of 88 patients who were admitted to the Chest Department to undergo bronchoscopy during the study period were included. A 176-bronchoalveolar lavage (BAL) samples were stained and cultured for bacteria and fungi. Isolated bacteria from the BAL samples were identified, and antimicrobial susceptibility testing was conducted. Statistical analysis was performed using the SPSS version 22 program. Results: Fifty-five (62.5%) of the patients were males, and 33(37.5%) were females. About 47(53.4%) of the BAL samples were positive bacterial cultures; 32(36.4%) of the BAL samples were positive fungal cultures. Among the isolated 39(83%) gram-positive bacteria, Streptococcus pneumoniae bacteria was the predominant pathogen in 35(89.7%) isolates. Among the isolated eight (17%) gram-negative bacteria, Pseudomonas aeruginosa was found to be the predominant organism in four (50%) isolates. Among the total of 32 fungal isolates samples, 15(46.9%) were Candida fungi detected, making it the most predominant pathogen. Conclusion: All bacteria as Streptococcus pneumoniae, Staphylococcal aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae were multiple drug resistance bacteria. Streptococcus pneumoniae is mainly susceptible to Rifampicin, whereas Gentamicin and Rifampicin are effective antimicrobial agents against Staphylococcal aureus. The effective antimicrobial agents against Pseudomonas aeruginosa were Amikacin, Colistin, Ceftazidime and Ciprofloxacin. Colistin and Doxycycline were the best effective drugs against each of Klebsiella pneumoniae and Escherichia coli. Additionally, Candida fungi were the most predominant pathogens.

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