EVALUATION OF SERUM ZINC LEVELS AND ITS RELATIONSHIP TO GLYCEMIC CONTROL AND LIPID PROFILE IN TYPE (2) DIABETES MELLITUS

Document Type : Original Article

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Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Abstract

Due to the importance of Zinc in glucose and lipid metabolism, it has been aimed in this study to investigate the association of serum zinc levels with glycemic control and lipid profile in type 2 diabetes mellitus patients (T2DM). This study has been conducted on 129 adult patients with diabetes at Tishreen University Hospital (TUH) and The Diabetes Center of Latakia City in Syria, and 51 matched healthy subjects. The results have shown a statistically significant decrease in serum zinc levels in T2DM patients compared with controls. A statistically significant negative correlation has been identified between zinc and all of HbA1C, BMI, duration of disease, and triglycerides, while a positive correlation has been observed with HDL levels in the diabetic group. In conclusion, this study has demonstrated that low zinc level is associated with poor glycemic control and it may give a cause to explain a possible association with dyslipidemia observed in T2DM patients.
 
 

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Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2
December 2022
Pages 1051-1061

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