IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE

Document Type : Original Article

Authors

1 Molecular Biology Department, Genetic Engineering and Biotechnology Institute, Sadat City University, Egypt

2 Internal Medicine Department, Rheumatology & Immunology Unit, Mansoura Faculty of Medicine, Mansoura University, Egypt

3 Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt

Abstract

Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE.
 

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Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2
December 2022
Pages 1085-1096

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