EVALUATION OF ADIPOSITY PHENOTYPES: LIPID ACCUMULATION PRODUCT INDEX, VISCERAL ADIPOSE INDEX AND BODY ROUNDNESS INDEX AS PREDICTOR MARKERS FOR METABOLIC SYNDROME DEVELOPMENT IN TYPE 2 DIABETES MELLITUS

Document Type : Original Article

Author

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Abstract

Visceral obesity is strongly associated with Metabolic syndrome (MetS) and increases the risk of cardiovascular disease in type II diabetes mellitus (T2DM). We aimed in this study to determine the best discriminator of obesity indexes to predict the occurrence of MetS in T2DM patients. The present study was conducted on 129 T2DM patients (Mets+: 70.54% & MetS-: 29.45%) during the period from 2020 to 2021. MetS+ patients have higher HbA1C, TG, and obesity indexes (BMI, WC, BF%, BRI, VAI, LAP) compared with MetS- group with a lower HDL-cholesterol in the MetS+ group. The average of  BF%, VAI, and LAP increased with increasing the number of MetS components according to NCEP-ATPIII criteria. In addition, the optimal cutoff points for obesity indexes were determined. Therefore, LAP with cutoff: 46.48 (AUC: 0.774, sensitivity: 80.2%, and specificity: 62.5%), VAI with cutoff: 1.73 (AUC: 0.668, sensitivity: 71.4%, and specificity: 54.2% ), and BRI with cutoff: 5.22 (AUC: 0.774, sensitivity: 82.4%, and specificity: 58.3%) seemed to be as useful indexes  in MetS prediction among T2DM patients. 
 

Keywords

Bulletin of Pharmaceutical Sciences Assiut University
Volume 45, Issue 2
December 2022
Pages 1097-1107

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