CLINICOPATHOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF PLATELET TO LYMPHOCYTE RATIO IN DIFFUSE LARGE B-CELL LYMPHOMA: A META-ANALYSIS

Saeed, Haitham; Shaaban, Mohamed EA; Abdelrahim, Mohamed E.A.

doi:10.21608/bfsa.2023.300949

CLINICOPATHOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF PLATELET TO LYMPHOCYTE RATIO IN DIFFUSE LARGE B-CELL LYMPHOMA: A META-ANALYSIS

Document Type : Original Article

Authors

¹ Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

² Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

10.21608/bfsa.2023.300949

Abstract

Background: Nowadays, there is a significant but variable correlation between the diffuse large B-cell lymphoma (DLBL) and the platelet-lymphocyte ratio (PLR). This meta-analysis will assess this association. Methods: A thorough search was done up until June 2022, and 11 research revealed 2284 patients with DLBL. They discovered a connection between DLBL and the PLR. A fixed or random-effect model was used to construct odds ratios (ORs) with 95% confidence intervals (CIs) and examine the prognostic significance of the PLR on overall survival, progression-free survival, and a variety of clinicopathological characteristics. Results: Poor 5-years overall survival (OR, 0.59; 95% CI, 0.36-0.98, p<0.001), poor 2-years progression-free survival subjects (OR, 0.42; 95% CI, 0.27-0.67, p<0.001), and poor 5-years progression-free survival (OR, 0.50; 95% CI, 0.34-0.72, p<0.001) were all significantly correlated with high the PLR. In a similar manner, a high the PLR was strongly correlated with the presence of B-symptoms (OR, 2.22; 95% CI, 1.69-2.93, p<0.001), a high lactate dehydrogenase level (OR, 2.98; 95% CI, 2.19-4.06, p<0.001), a higher tumour stage (OR, 1.84; 95% CI, 1.08-3.13, p=0.03). Nevertheless, there was no significant correlation between a high the PLR and a high Eastern Cooperative Oncology Group performance status ≥2 (OR, 1.44; 95% CI, 0.69-3.02, p=0.33), a high bone marrow infiltration (OR, 1.02; 95% CI, 0.60-1.74, p=0.94), a person's gender (OR, 1.20; 95% CI, 0.93-1.55, p=0.17); age (OR, 0.89; 95% CI, 0.69-1.15, p=0.37); and cell of origin (OR, 1.00; 95% CI, 0.71-1.39, p=0.98). Conclusions: The impact of the PLR on DLBL may be substantial as a technique to enhance prognosis. Patients with DLBL who have a high the PLR may be at an independent risk for having a poor prognosis. To prevent potential problems, we advise keeping track of patients with a high platelet-to-lymphocyte ratio.

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