CORRELATION BETWEEN HIGH SENSITIVITY C-REACTIVE PROTEIN AND LIPID PROFILE IN YOUNG PATIENTS WITH DIABETES MELLITUS TYPE 1 IN HOMS-SYRIA

Document Type : Original Article

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Department of Biochemistry and Microbiology, Al-Baath university, Homs, Syria

Abstract

In this study, we evaluated levels of high sensitivity C-reactive protein (hsCRP), as a predictor marker of cardiovascular disease, and  lipid profile and studied the relationship between them  in young patients with diabetes mellitus type 1 (DMT1). This study was conducted on 71 young with (DMT1), at Al-Arman Healthy Center in Homs- Syria, compared to 25 healthy controls at the same age. Blood samples were collected, and laboratory measurements were performed which included: HbA1c, FBG, TG, LDL-c, HDL-c, TC, hsCRP. Depending on the (HbA1c) values, all study patients had uncontrolled DM, and 58.5% of them had dyslipidemia. DMT1 patients had significantly higher serum concentrations of hsCRP, which indicates the presence of low-grade chronic inflammation. Significant positive correlation was found between (hsCRP) and (HbA1c, TG, LDL-c, TC), and a significant negative correlation with (HDL-c) in DMT 1 group. Conclusions, Atherosclerosis and vascular changes begin from an early age in DMT 1 patients with poor glycaemic control.

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Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2
December 2023
Pages 1077-1084

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