Document Type : Original Article
Authors
1
Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt Pharmaceutical and Drug Industries Research Division, National Research Centre, 33–El Behouth St., 12622, Giza, Egypt
2
Medicinal and Pharmaceutical Chemistry Department, National Research Centre, 33–El Behouth St., 12622, Dokki, Giza, Egypt
3
Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Giza, Egypt
Abstract
Blueberries are rich in anthocyanins, which have been studied for many years. Interest in these compounds has grown attributing to their possible therapeutic and beneficial effects. Therefore, this study aimed to investigate the potential antioxidant, anti-inflammatory, hepatoprotective, anti-diabetic, and anti-inflammatory effects of blueberry fruit extract supplement (25% anthocyanin) in combination with aloglibtin and voglibose in streptozotocin (STZ)-induced diabetic rats.
Diabetes mellitus was induced in six groups with a single 45 mg/kg STZ injection. However, 5 of these groups were treated with alogliptin (Alog), voglibose (Vog), blueberry fruit extract (BB-fruit extract), combined treatment of (Alog + BB-fruit extract), and (Vog + BB-fruit extract), respectively, for three weeks. Serum glucose, C-peptide, lipid profile, liver enzymes, kidney enzymes, and TNF-α levels were estimated. Meanwhile, alpha-glucosidase, catalase, and superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were determined in rats' liver tissues.
All diabetic groups unveiled a significant decrease in serum glucose and C-peptide level after administering BB-fruit extract. Combination of BB-fruit extract and vog is effective in achieving sufficient glycemic control by significantly reducing inflammation, oxidative stress, hyperlipidemia, and hyperglycemia. These findings imply that this combination is an effective strategy for controlling diabetes.
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