Document Type : Original Article
Authors
1
Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Sphinx University, New Assiut City, Assiut, Egypt
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University,Sohag, Egypt.
3
Department of Histology and Cell biology, Faculty of Medicine, Sohag University, Sohag, Egypt
Abstract
Background: Currently, using medicinal herbs has a great interest in the treatment of nonalcoholic fatty liver disease (NAFLD). This study evaluated the impact of stevia on the hallmark signs of dexamethasone-induced NAFLD in rats. Methods: Group I: Negative control rats received 2 ml of vehicle carboxy methyl cellulose (CMC). Group II: Rats received dexamethasone 8 mg/kg/day intraperitoneal for 6 days. Group III: Rats received oral stevia extract 400 mg/kg/day for 12 days. Group IV: Rats received dexamethasone + stevia extract. Serum ALT, AST, TC, TG and adiponectin were measured. MDA, GPx and TNF-α were estimated in liver homogenate. Histopathological changes and PPAR-α expressions in the liver were evaluated. Results: Dexamethasone caused a reduction in GPx and ADP levels with an elevation in ALT, AST, TC, TG, MDA and TNF-α. There was a decrease in immunostaining expression of liver PPAR-α. Stevia caused an improvement in liver enzymes, lipid profile, oxidative stress, TNF-α and adiponectin levels. Conclusion: Stevia provided some protection against dexamethasone-induced NAFLD.
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