LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES

Document Type : Original Article

Authors

1 pharmacology and toxicology-collage of medicine- Wasit university

2 Department of Pharmacology, College of Medicine, Wasit University, Iraq

3 Department of Microbiology, College of Medicine, Wasit University, Iraq

4 Department of Medical Elementology & Toxicology, School of Chemical and Life Science, Jamia Hamdard, New Delhi -110062

5 Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India

6 Department of Biochemistry, Faculty of Science, Damanhour University, Egypt

Abstract

Background: With the rapid increase in the use of electronic cigarettes as a prevalent form of nicotine, numerous studies have reported that their use has potentially negative health effects. Objectives: Evaluate and compare the effects of electronic cigarettes and traditional cigarettes on lung tissue. Study Design and Methodology: Twenty-five male Wistar rats were split into three groups: the EC Group was treated to e-cigarette liquid vapor, the CC Group to conventional smoke, and the control group without nicotine. Result: Significant alterations were observed in both experimental groups., including an increase in thickness of the alveolar wall, infiltration of inflammatory cells, collapsed vacuole in the wall of alveoli, and focal infiltration of lymphocytes in the wall of the bronchiole. Additionally, there was up-regulation of SODs gene expression in both groups. Conclusion: Histo-pathological analysis suggests that smoking and vaping are equally harmful to lung tissue. Real-time PCR analysis revealed significant up-regulation of SODs gene expression in conventional cigarettes and electronic cigarettes compared to the control group
Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2
December 2023
Pages 1429-1440

Files

Share

How to cite

Statistics