EVALUATION AND PREPARATION OF ATENOLOL-LOADED FLOATING MICROCAPSULES

Hammodi, Hayder; El-Dahan, Marwa S.; Borg, Thanaa M.

doi:10.21608/bfsa.2023.327655

EVALUATION AND PREPARATION OF ATENOLOL-LOADED FLOATING MICROCAPSULES

Document Type : Original Article

Authors

¹ Department of Pharmacy Mazaya University college, Thai-Qar, Iraq

² Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University

10.21608/bfsa.2023.327655

Abstract

The aim of this investigation is to prepare Atenolol (AT) floating microcapsules with sustained release profiles utilizing ethyl cellulose (EC) as a matrix former. EC is frequently used as a hydrophobic polymeric material for extended drug release applications. Emulsion-solvent evaporation technique was utilized to fabricate the floating microcapsules. The ratios of EC and AT utilized were 1:1, 1:2, 1:3, 1:4, and 1:5, with the amount of EC used being constant and the amount of AT being variable depending on the polymer ratio/AT ratio. The prepared microcapsules were assessed for entrapment efficiency (EE%), drug loading, percent yield (% yield), buoyancy percentage (%), particle size analysis, and in-vitro drug release study after 12 h. After that, the best-achieved microcapsule was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The best formula (M1) demonstrated a spherical morphology. Further, M1 released about 91.23 ± 3.21% after 12 h. Moreover, the FTIR showed that their no chemical interaction between the formulation components. In addition, DSC showed the ability of microcapsules to enclose AT inside its constructs. Further, XRD studies showed that microcapsules had an amorphous form. The previous findings demonstrated the good capability of M1 as a floating dosage form for sustained and continuous drug delivery of AT.

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