ADVANCEMENTS IN NANOPARTICLE-BASED RNA THERAPEUTICS AND RNA DELIVERY SYSTEMS

Al-Hamdani, Mais Mazin; Noori, Sarmad Dheyaa; Kassem, Amira B

doi:10.21608/bfsa.2023.327759

ADVANCEMENTS IN NANOPARTICLE-BASED RNA THERAPEUTICS AND RNA DELIVERY SYSTEMS

Document Type : Review Article

Authors

¹ Department of Pharmaceutics- College of Pharmacy - Al-Ayen University.

² Department of Pharmaceutical Chemistry, College of Pharmacy ,Al-Ayen University

³ Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damnhour University Department of Clinical Pharmacy, Collage of Pharmacy, Al-Ayen University

10.21608/bfsa.2023.327759

Abstract

Indeed, because of their potential to overcome some of the limitations of synthetic polymer-based nanoparticles, the usage of RNA-based nanoparticles has attracted substantial interest in recent years. Because RNA is a naturally occurring molecule that can be easily synthesized and manipulated to attain certain features, it is an appealing platform for the generation of nanoparticles. Drug delivery, gene therapy, and imaging have all been investigated using RNA-based nanoparticles. One of its advantages is RNA-based nanoparticles' biocompatibility, making them less likely to produce toxicity or unfavorable effects in biological systems. Furthermore, RNA-based nanoparticles can be made to be very selective, allowing therapeutic medicines to be delivered to specific cells or tissues. This selectivity is achieved by creating RNA molecules that recognize and bind to specific targets such as cancer cells or virus particles. Because RNA-based nanoparticles are biodegradable and do not persist in the environment, they have the potential to be more environmentally friendly than synthetic polymer-based nanoparticles. As a result, the usage of RNA-based nanoparticles may lessen the potential for negative effects on aquatic and other habitats. Overall, the development of RNA-based nanoparticles has opened up new possibilities for medicinal delivery and other applications. While there are still obstacles to overcome, such as optimizing their stability and efficacy, the potential benefits of these nanoparticles make them an intriguing area of research in nanotechnology.

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