Anti-obesity action of green tea extract and curcumin: Role of c1q/TNF-related protein-12 (CTRP-12) and caspase-2.

Document Type : Original Article

Authors

1 Department of Biochemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt

3 Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.

4 Department of Biochemistry, Faculty of Pharmacy, Sphinx University, New Assiut, Egypt

Abstract

Background: The prevalence of obesity is increasing. It is regarded to be among of the world's biggest health issues and the primary factor in metabolic syndrome, a group of illnesses including hypertension, diabetes mellitus, and dyslipidemia. Many studies proved the efficacy of dietary polyphenols ascurcuminand green tea extractin ameliorating obesity and its correlated disorders.

Methods: Our work was the first to explore the impact of green tea extract and curcumin on the insulin-sensitizing anti-inflammatory adipokine C1q/ TNF-related protein-12 (CTRP-12)serum level measured by ELISA and expression of caspase-2 in white adipose tissue invivo measured by qRT-PCR.

Results: We found that both green tea extract and curcumin elevated serum CTRP-12 level. Moreover, they stimulated adipocytes apoptosis via increasing the expression of caspase-2 decreasing adiposity.

Conclusion: The current study concludes that green tea extract and curcumin have prophylactic effect against obesity and obesity-related disorders.



Keywords: high-fat diet, caspase-2, CTRP-12, green tea extract, curcumin.

Keywords

Bulletin of Pharmaceutical Sciences Assiut University

Articles in Press, Accepted Manuscript
Available Online from 25 December 2023

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