The synthesis of twenty nine novel derivatives of pyrazolo[3,4-d]pyrimidines as non acidic nonsteroidal anti-inflammatory drugs has been achieved via reaction of 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine with different substituents including 4-amino-3-methylphenol, 4-phenylene diamine and 4-acetamidophenol.The anti-inflammatory activity of thirteen representative compounds have been screened compared to indomethacin as a reference drug. The results revealed that all the tested compounds showed anti-inflammatory activity with the exception of 10a.
Abbas, S., Georgey, H., Abdelrahman, S., & El-Taliawi, G. (2008). SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY. Bulletin of Pharmaceutical Sciences Assiut University, 31(2), 197-214. doi: 10.21608/bfsa.2008.345095
MLA
Safinaz E. S. Abbas; Hanan H. Georgey; Shimaa M. Abdelrahman; Gamil M. El-Taliawi. "SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY". Bulletin of Pharmaceutical Sciences Assiut University, 31, 2, 2008, 197-214. doi: 10.21608/bfsa.2008.345095
HARVARD
Abbas, S., Georgey, H., Abdelrahman, S., El-Taliawi, G. (2008). 'SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY', Bulletin of Pharmaceutical Sciences Assiut University, 31(2), pp. 197-214. doi: 10.21608/bfsa.2008.345095
VANCOUVER
Abbas, S., Georgey, H., Abdelrahman, S., El-Taliawi, G. SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY. Bulletin of Pharmaceutical Sciences Assiut University, 2008; 31(2): 197-214. doi: 10.21608/bfsa.2008.345095
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