EXPLORING THE POTENTIAL HEPATOPROTECTIVE EFFICACY OF LEPIDIUM SATIVUM SEEDS: A COMPREHENSIVE REVIEW

Sawan, Eman. S; Abdelhadi, Alaa A.; Elsyed, Kareem H.; Elsayed, Nora H.; Yassen, Heba R.; Mohammed, Manar R.; Ahmed, Nadeen. S.; Zahran, Manar K.; Elkest, Nada M.; Hammad, Omar; Shimaa Abdelsattar, Shimaa; Hussein, Raghda; Abdel-Latif, Mohamed M.; Aly, Shaza H.

doi:10.21608/bfsa.2024.276705.2061

EXPLORING THE POTENTIAL HEPATOPROTECTIVE EFFICACY OF LEPIDIUM SATIVUM SEEDS: A COMPREHENSIVE REVIEW

Document Type : Original Article

Authors

¹ Department of Clinical Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

² Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

³ Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menofia University

⁴ Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

⁵ Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University

⁶ Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829

10.21608/bfsa.2024.276705.2061

Abstract

Abstract: Background: Chronic liver diseases are the leading cause of morbidity and mortality worldwide.Lepidium sativum (L. sativum) is a famous member of the Bras-sicaceae family that has been utilized for medicinal and culinary purposes for cen-turies. The hepatoprotective activity of various portions of the plant has been re-ported in several experimental and clinical trials. Aim: The current review study aimed to discuss the hepatoprotective effects of L. sativum seeds. Methods: The da-ta of this review were collected from English-language in-vivo and in-vitro studies published in electronic databases; with no time limit; including Web of Science, Scopus, MEDLINE, Google Scholar and PubMed. The searched keywords were “Lepidium sativum” and/or “chemical composition”, “Hepatoprotective”, “liver diseases”. Results: Lepidium sativum seeds significantly decreased the elevated in-flammatory markers and oxidative stress in hepatic tissues. The seed extract signifi-cantly lowered serum levels of ASP, ALT, and bilirubin. The potential molecular mechanism may be through upregulating Bcl-2 protein expression and downregu-lating caspase-3. Conclusion: Lepidium sativum seeds are promising hepatoprotec-tive natural remedy through their multi-targeted action on different pathophysio-logical mechanisms involved in liver diseases.

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