CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS

MORONKEJI, Akinpelu; Adeniyi, Temidayo D; Oyeleke, Abiodun; Igunbor, Chuks M; AYENI, Joy Olajumoke; ADELABI, Toluwanimi Olanike; Moronkeji, Adebimpe

doi:10.21608/bfsa.2024.297319.2162

CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS

Document Type : Original Article

Authors

¹ Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria.

² Department of Medical Laboratory Science, College of Health Sciences, University of Ilorin, Kwara State Nigeria.

³ Department of Anatomy, Federal University Oye-Ekiti, Ekiti State, Nigeria

⁴ Department of Medical Laboratory Science, Achievers University Owo, Ondo State, Nigeria

⁵ Department of Medical Laboratory Science, Faculty of Allied Health Sciences University of Medical Sciences Ondo, Nigeria.

⁶ Department of Medical Laboratory Science, Elizade University Ilara Mokin, Ondo State Nigeria.

10.21608/bfsa.2024.297319.2162

Abstract

Pharmaceuticals typically induce toxicity in the liver and kidney, which are primary control mechanisms for maintaining bodily homeostasis and are more vulnerable to xenobiotics. Cymbopogon citratus (West Indian lemon grass) is used in traditional medicine globally for a variety of medicinal purposes. This study aimed to determine the therapeutic effectiveness of a methanolic leaf extract of C. citratus against NSAID-induced hepatorenal toxicity in adult Wistar rats (Rattus norvegicus domestica). Twenty rats weighing 180–220g were randomly assigned to four groups of five rats each. The unexposed control rats (Group 1) were administered distilled water, while the NSAID-exposed rats (Group 2-4) received Diclofenac at 5mg/kg/BW. While rats in Group 2 were untreated, rats in Groups 3 and 4 were treated with methanolic leaf extracts of C. citratus at 100mg/kg/BW and 200mg/kg/BW, respectively. Treatment with the methanolic extract of C. citratus modulates TNF-α and IL-10 expression (P<0.05) and ameliorates cellular alterations in the kidneys and liver of treated rats compared to the untreated group. This study established the efficacy of Cymbopogon citratus as a hepatorenal protector by considerably ameliorating the adverse effects of diclofenac-induced hepatorenal toxicity.

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