Document Type : Original Article
Authors
1
Pharmaceutical Inspection, General Administration of Pharmacists, Assiut, Egypt
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University
3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
Abstract
Flavonoids are bioactive compounds derived from plants that significantly influence the health of individuals. Morin hydrate (MH) is a bioactive compound of botanical origin easily available in various plants' leaves, stems, fruits, and branches of the family Moraceae. Morin can exert a beneficial impact on various disorders, owing to its antioxidative, anti-inflammatory, antidiabetic, cardioprotective, anti-arthritis, anti-tumor, nephroprotective, and protective effects in many neurodegenerative diseases. In many cases, Morin exhibits systemic protective effects, mitigating the adverse effects of various medications without compromising their efficacy. It exhibits these potential pharmacological actions through different mechanisms such as influencing the activity of various enzymes, scavenging free radicals, enhancing or reducing the level of various inflammatory mediators, increasing or decreasing the expression of many proteins, and boosting or suppressing a variety of intracellular signaling cascades. Several findings indicate that MH can prevent a variety of human pathologies, either on its own or in conjunction with other medications. Moreover, many studies performed in vivo and in vitro showed that Morin has very low toxicity levels and is well tolerated when taken over an extended period. This article presents recent studies on the biological and pharmacological properties, as well as the molecular mechanisms of Morin hydrate to elucidate its many positive health impacts.
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