ANTI-INFLAMMATORY PROPERTIES OF CAPSICUM EXTRACT FROM ALGERIAN RED CHILI PEPPER: EVALUATION AND FORMULATION OF A TOPICAL PREPARATION

Articles in Press

Document Type : Original Article

Authors

1 Department of Process Engineering, Faculty of Technologies, M'Hamed Bougara University, Boumerdes, Algeria

2 Department of Chemistry, Faculty of Science, Mouloud Mammeri University, Tizi-Ouzou, Algeria

3 National Laboratory for the Control of Pharmaceutical Products (LNCPP), Algiers, Algeria

4 Department of Pharmacy, Faculty of Medicine, Mouloud Mammeri University, Tizi-Ouzou, Algeria

Abstract

Capsaicin is a natural compound with anti-inflammatory and analgesic properties. effective in conditions like rheumatoid arthritis when administered orally or topically. Despite Algeria being the world’s ninth-largest chili producer in 2012, its therapeutic potential remains underexplored. This study investigates the anti-inflammatory activity of an ethanol extract from Capsicum annuum fruits cultivated in Algeria and assess the efficacy of a corresponding topical ointment in a mouse ear edema model.

The extract, rich in capsaicin and β-carotene, was obtained via Soxhlet extraction using 96% ethanol. UV–visible spectrophotometry and HPLC confirmed the presence of capsaicin and dihydrocapsaicin in an approximate 4:3 peak area ratio.

Anti-inflammatory activity was assessed using a mouse ear edema model induced by xylene. The results of this study demonstrate that Capsicum extract exhibits significant anti-inflammatory activity. A 0.13 g/mL concentration of the Capsicum extract reduced edema weight by 75.13%. Furthermore, a topical ointment formulated with the extract produced an 85% reduction in edema.

These results suggest that Capsicum annuum extract exhibits potent anti-inflammatory effects and holds promise for topical therapeutic applications

Keywords

Bulletin of Pharmaceutical Sciences Assiut University

Articles in Press, Accepted Manuscript
Available Online from 06 July 2025

Files

Share

How to cite

Statistics