PHYTOCHEMICAL AND BIOLOGICAL STUDY OF PETREA VOLUBILIS L. (VERBENACEAE)

Document Type : Original Article

Authors

1 Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

2 Department of Health Information Technology, Jeddah Community College, King Abdul-Aziz University, 21589 Jeddah Saudi Arabia

Abstract

Petrea volubilis L. was studied for its secondary metabolites and biological activities. The
phytochemical screening of dried aerial parts revealed the presence of different constituents
such as unsaturated sterols, triterpens, and flavonoids. The biological activities of the total
extract and different fractions were evaluated in a series of bioassays (antioxidant, antiinflammatory,
analgesic, antipyretic and antibacterial), the majority of them showed significant
activities in the applied test systems. Extensive purification of the ethyl acetate extract led to
isolation of apigenin (1), quercetin (2), 4`, 6-dimethylscutellarien (3), hypogallic acid (3,4-
dihydroxybenzoic acid) (4), trans-caffeic acid (5) vanillic acid (6) and acteoside (7). The
structure elucidation of 1-7, was carried out by 1H-NMR, UV and MS analyses.

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