IMIDAZOLE ALKALOIDS FROM THE INDOPACIFIC SPONGE PERICHARAX HETERORAPHIS

Ali, A. A.; Hassanean, H. A.; Elkhayat, Ehab S.; Edrada, Ru AnGelie; Ebel, Rainer; Proksch, Peter

doi:10.21608/bfsa.2007.64196

IMIDAZOLE ALKALOIDS FROM THE INDOPACIFIC SPONGE PERICHARAX HETERORAPHIS

Document Type : Original Article

Authors

¹ Department of Pharamcocnosy, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt

² Department of Pharamcocnosy, Faculty of Pharmacy, Al-Azhar University (Assiut branch , 71524 Assiut, Egypt)

³ Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, 40225 Düsseldorf, Germany

10.21608/bfsa.2007.64196

Abstract

Chemical investigation of the sponge Pericharax heteroraphis (Polejeff) collected in Indonesia, has led to the isolation of three imidazole alkaloids, preclathridine-A (1), leucettamine-B (2) and leucettamine-A (3). The structures of the isolated compounds were unambiguously established by 1D and 2D NMR and mass data. This is the first report of this class of compounds from the P. heteroraphis sponge. Investigation of the antimicrobial activities of the isolated compounds showed that leucettamin-A (3) was active against the gram-positive bacteria Staphylococcus aureus and the fungus Cladosporium herbarum, while other compounds were inactive.