Four series of new acridine derivatives of anticipated antitumor activity have been designed and synthesized. The first series belongs to 4-substituted phenylhydrazinocarbonylmethyl 9-oxo- 9,10-dihydroacridine-4-carboxylate 10a-h. The second series consists of phenylhydrazinocarbonylmethyl 9-(4-substituted phenyl)aminoacridine-4-carboxylate 12a-k, while the third series comprises 4-substituted phenylcarbamoylmethyl 9-(4-substituted phenyl)aminoacridine-4-carboxylate 15a-k. The fourth one belongs to phenylcarbamoylmethyl 9-(4-substituted phenyl)aminoacridine- 4- carboxylate 17a-j. The chemical structure of synthesized compounds was elucidated by spectral data and elemental analysis. Seventeen selected compounds (10a, 10g, 10h, 12a, 12d, 12g, 12h, 12k, 15a, 15c, 15g, 15h, 15k, 17a, 17f, 17g and 17j) were tested against breast cancer cell line (MCF7) and eight compounds (12g, 12h, 12k, 15g, 15h, 17f, 17g, 17j) were found to exhibit significant antitumor activity
El-Moghazy Aly, S., Abdel Rahman, D., -S. Abbas, S., - A. Mohammed, M., & Amin, A. (2007). DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY. Bulletin of Pharmaceutical Sciences Assiut University, 30(2), 213-234. doi: 10.21608/bfsa.2007.64201
MLA
S. M. El-Moghazy Aly; D. E. Abdel Rahman; S. E. -S. Abbas; M. A. - A. Mohammed; A. H. Amin. "DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY", Bulletin of Pharmaceutical Sciences Assiut University, 30, 2, 2007, 213-234. doi: 10.21608/bfsa.2007.64201
HARVARD
El-Moghazy Aly, S., Abdel Rahman, D., -S. Abbas, S., - A. Mohammed, M., Amin, A. (2007). 'DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY', Bulletin of Pharmaceutical Sciences Assiut University, 30(2), pp. 213-234. doi: 10.21608/bfsa.2007.64201
VANCOUVER
El-Moghazy Aly, S., Abdel Rahman, D., -S. Abbas, S., - A. Mohammed, M., Amin, A. DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY. Bulletin of Pharmaceutical Sciences Assiut University, 2007; 30(2): 213-234. doi: 10.21608/bfsa.2007.64201
)
View on SCiNiTO