A sensitive and selective spectrofluorimetric method has been developed for the determination of some non-steroidal antiinflammatory oxicams derivatives namely: tenoxicam (Tx), piroxicam (Px) and lornoxicam (Lx) after their complete oxidative acidic hydrolysis to 2-aminopyridine. The hydrolytic product 2- aminopyridine exhibits fluorescence emission at 365 nm (excitation at 305 nm). The optimal conditions of the reaction were investigated. The method was found to be linear in the ranges of (0.015-0.500 μg/ml) for Tx (0.006-0.300 μg/ml) for Px and (0.060- 0.200 μg/ml) for Lx. The suggested method was successively applied for the determination of the studied drugs in different dosage forms with a recovery percentages ranged 96.82-102.79 ± 0.614-2.578. The method was also applied for the determination of the drugs in spiked urine with a recovery percentages ranged 80.51-105.35 ± 1.067-5.338. The validity of the method was assessed according to USP guidelines. Statistical analysis of the results reveled high accuracy and good precision.
Abdel-Wadood, H. (2008). SPECTROFLUORIMETRIC METHOD FOR DETERMINATION OF SOME OXICAMS USING POTASSIUM BROMATE. Bulletin of Pharmaceutical Sciences Assiut University, 31(2), 169-181. doi: 10.21608/bfsa.2008.64222
MLA
Hanaa M. Abdel-Wadood. "SPECTROFLUORIMETRIC METHOD FOR DETERMINATION OF SOME OXICAMS USING POTASSIUM BROMATE". Bulletin of Pharmaceutical Sciences Assiut University, 31, 2, 2008, 169-181. doi: 10.21608/bfsa.2008.64222
HARVARD
Abdel-Wadood, H. (2008). 'SPECTROFLUORIMETRIC METHOD FOR DETERMINATION OF SOME OXICAMS USING POTASSIUM BROMATE', Bulletin of Pharmaceutical Sciences Assiut University, 31(2), pp. 169-181. doi: 10.21608/bfsa.2008.64222
VANCOUVER
Abdel-Wadood, H. SPECTROFLUORIMETRIC METHOD FOR DETERMINATION OF SOME OXICAMS USING POTASSIUM BROMATE. Bulletin of Pharmaceutical Sciences Assiut University, 2008; 31(2): 169-181. doi: 10.21608/bfsa.2008.64222