SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS

Hayallah, Alaa M.; Heta, Helal F.

doi:10.21608/bfsa.2008.64342

SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS

Document Type : Original Article

Authors

Alaa M. Hayallah ¹
Helal F. Heta ²

¹ Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

² Department of Microbiology and immunology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt

10.21608/bfsa.2008.64342

Abstract

In the present work, some new 1,3,5-trisubstituted[1,2,4]triazole derivatives and their Schiff's bases were synthesized. The chemical structure of the target compounds was confirmed by IR, 1H-NMR, 13C-NMR, FAB-MS, EI-HRMS spectra and elemental analyses. The title compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative ones using ampicillin and nalidixic acid as reference drugs. Some of them showed antibacterial activity more significant than the reference drugs.