ANTIOXIDANT, LIPID PEROXIDATION-INHIBITORY AND ANTIULCER ACTIVITIES OF BROWN PROPOLIS

Document Type : Original Article

Authors

1 Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.

2 Department of Pharmacology and oxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

3 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524,Egypt

Abstract

The antioxidant activity of the ethanolic extract of brown propolis was determined by invitro
antioxidant assays via 1,1-diphenyl-2-picryl-hydrazyl (DPPH·) free radical scavenging
activity and phosphomolybdenum method. The brown propolis extract had an effective DPPH·
scavenging activity at 20-200ìg/ml concentrations. Moreover, the in-vivo experiments showed
that brown propolis extract has a powerful antioxidant and lipid peroxidation inhibitory activity
in the liver tissues challenged with CCl4. On the other hand, we found that pretreatment of rats
with propolis extract protected gastric tissues against indomethacin-induced gastropathy as
demonstrated from reduction in the ulcer index, attenuation of histopathological changes and
amelioration of the altered oxidative stress biomarkers like glutathione, thiobarbituric acid
reactive substance levels and superoxide dismutase act ivi ty in gastric tissues. In conclusion,
total ethanolic extract of brown propolis exposed major anti-oxidant and anti-ulcer activities.

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