SYNTHESIS OF SOME PYRIMIDINE DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITIES

Document Type : Original Article

Authors

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt

2 Department of Pharmaceutical Sciences, National Research Center, Dokki, Giza

3 Hot Labs. Center, Atomic Energy Authority, Cairo, Egypt

Abstract

A series of 4-substituted pyrimidines and fused pyrimidine ring system e.g. pyrido[2,3-d] pyrimidine were synthesized and the antitumor activity have been carried out for 8 compounds. Compound 4a also, which carries the pharmacophoric group IDA was tested for the hepatobilliary imaging effect.

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