Two new metabolites, a diglyceride ester, corticaglyceride (1) and a sphingolipid, corticaceramide (5) were isolated and characterized from the Red Sea sponge Negombata corticata (Carter). Other previously reported compounds including nervonic acid (2), 24-methylene cholesterol (3) and cholesterol (4) were also isolated for the first time from this genus. GLC analysis of the unsaponifiable matter revealed that it contained a high percentage of hydrocarbons (89.474%) with n-hexacosane as a major component (10.979%). Furthermore, the identified sterol represents 7.162%. GLC analysis of the fatty acid methyl esters revealed that nervonic acid is the major fatty acid (73.782%). Compound 3 showed anti-inflammatory activity, while compounds 1 and 5 showed mild anti-oxidant properties.
Ahmed, S., Mesbah, M., Youssef, D., & Khalifa, S. (2006). CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA. Bulletin of Pharmaceutical Sciences Assiut University, 29(1), 151-165. doi: 10.21608/bfsa.2006.65189
MLA
Safwat Ahmed; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa. "CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA". Bulletin of Pharmaceutical Sciences Assiut University, 29, 1, 2006, 151-165. doi: 10.21608/bfsa.2006.65189
HARVARD
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. (2006). 'CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA', Bulletin of Pharmaceutical Sciences Assiut University, 29(1), pp. 151-165. doi: 10.21608/bfsa.2006.65189
VANCOUVER
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA. Bulletin of Pharmaceutical Sciences Assiut University, 2006; 29(1): 151-165. doi: 10.21608/bfsa.2006.65189
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