CYTOTOXIC PHENOLICS FROM THE FLOWERS OF HIPPEASTRUM VITTATUM

Document Type : Original Article

Author

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

Abstract

Bioassay-guided fractionation and purification of the ethanolic extract of the fresh flowers of Hippeastrum vittatum (Amaryllidaceae) cultivated in Egypt yielded three compounds viz. caffeic acid (1), dihydrocaffeic acid methyl ester (2), together with the polyhydroxylated alkaloid pancratistatin (3). The structures of the isolated compounds were determined on the basis of extensive 1D (1H and 13C) and 2D (COSY, HMQC, and HMBC) NMR studies, and mass spectral measurements. The cytotoxic activity of compounds 1-3 is presented and discussed