BIOTRANSFORMATION OF INDOLE ALKALOID BY TERRESTRIAL STREPTOMYCES GW 14/587 STRAIN INTO A SELECTIVE PHYCOTOXIC AGENT

Haggag, E. G.; Laatsch, H.

doi:10.21608/bfsa.2004.65420

BIOTRANSFORMATION OF INDOLE ALKALOID BY TERRESTRIAL STREPTOMYCES GW 14/587 STRAIN INTO A SELECTIVE PHYCOTOXIC AGENT

Document Type : Original Article

Authors

E. G. Haggag ¹
H. Laatsch ²

¹ Department of Pharmacognosy, Faculty of Pharmacy, Helwan University at Ain Helwan, Cairo, 11795 Egypt

² Department of Organic Chemistry, George-August-University, Tammann Strasse 2, Gottingen, 27570, Germany

10.21608/bfsa.2004.65420

Abstract

Methyl indole was isolated as a metabolite from the culture broth of terrestrial Streptomyces GW 14/587 strain which was fed with indole after two days growth and then inoculated for another two, three and four days to optimize the experiment condition for highest metabolite concentration. The structure of the isolated methyl indole was established using spectral techniques of HPLC-MS, EI-MS, 1H and 13CNMR. Also the bacterial extract showed a high selective phycotoxic activity against Scendensmus subspicatus among the different tested microalgae, yeast, fungi and bacteria.