Vilsmeier formylation of acetanilide I followed by treatment with hydroxylamine produced 2-chloroquinoline-3-carbonitrile II that was condensed with different amines to give 2- substituted aminoquinolines-3-carbonitriles III. Treatment of II with thiourea yielded 2- mercaptoquinoline-3-carbonitrile IV, which was converted to its potassium salt V that was condensed with some chloroacetate esters to produce 2-substituted thioquinoline-3- carbonitriles VI. Hydrazinolysis of II or IV gave 1H-pyrazolo[3,4-b]quinolin-3-ylamine VII. Condensation of VII with different aryl aldehydes resulted in the corresponding imines VIII. Treatment of VII with p-chloro-benzoyl chloride afforded the amide IX. Some of the synthesized compounds were evaluated for their antibacterial and antifungal activity.
Amin, M., Ismail, M., Barakat, S., Abdul-Rahman, A., Bayomi, A., & El-Gamal, K. (2004). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES. Bulletin of Pharmaceutical Sciences Assiut University, 27(2), 237-245. doi: 10.21608/bfsa.2004.65452
MLA
Monir A-S. Amin; Mohammed M. Ismail; Saber E-S. Barakat; Ashraf A-A. Abdul-Rahman; Ashraf H. Bayomi; Kamal M.A. El-Gamal. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES". Bulletin of Pharmaceutical Sciences Assiut University, 27, 2, 2004, 237-245. doi: 10.21608/bfsa.2004.65452
HARVARD
Amin, M., Ismail, M., Barakat, S., Abdul-Rahman, A., Bayomi, A., El-Gamal, K. (2004). 'SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES', Bulletin of Pharmaceutical Sciences Assiut University, 27(2), pp. 237-245. doi: 10.21608/bfsa.2004.65452
VANCOUVER
Amin, M., Ismail, M., Barakat, S., Abdul-Rahman, A., Bayomi, A., El-Gamal, K. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES. Bulletin of Pharmaceutical Sciences Assiut University, 2004; 27(2): 237-245. doi: 10.21608/bfsa.2004.65452
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