Bioadhesive vaginal tablets of natamycin were formulated with different bioadhesive polymers such as carbopol 971p, carbopol 974p, hydroxypropyl methylcellulose, and sodium carboxymethylcellulose. Physical tests were applied to the tablets. The bioadhesive tablets were evaluated for drug release rate and swelling behaviour in citrate buffer solution and bioadhesive strength to mucosal tissue of cow vagina. The swelling of the tablets containing carbopol 974p was found to last for up to 6 hr in citrate buffer solution. The force necessary to detach the tablets from the vaginal tissue was found to be dependent on the concentration and type of the bioadhesive polymer. The bioadhesive polymers were found to decrease the drug release rate. However, inclusion of polyethylene glycol 6000 in the formulations increased the released amount of the drug from 6.35% to 38.83% after 12 h. The bioadhesive tablets were clinically evaluated in volunteers suffering from vaginal candidiasis and compared with conventional natamycin vaginal tablets. It was found that the bioadhesive tablets were more effective than the conventional tablets as they lasted about 4 days in the vaginal cavity and this could sustain the drug release and lead to better patient compliance. Accelerated stability studies were carried out and showed that the selected formulations were stable for not less than 2.5 years.
El-Gindy, G., El-Sayed, A., Mohame, S., & Abdel-Aal, G. (2003). MUCOADHESIVE VAGINAL TABLETS OF NATAMYCIN FOR VAGINAL CANDIDIASIS. Bulletin of Pharmaceutical Sciences Assiut University, 26(1), 29-40. doi: 10.21608/bfsa.2003.65465
MLA
G. A. El-Gindy; A. M. El-Sayed; S. A. Mohame; Gh. M. Abdel-Aal. "MUCOADHESIVE VAGINAL TABLETS OF NATAMYCIN FOR VAGINAL CANDIDIASIS". Bulletin of Pharmaceutical Sciences Assiut University, 26, 1, 2003, 29-40. doi: 10.21608/bfsa.2003.65465
HARVARD
El-Gindy, G., El-Sayed, A., Mohame, S., Abdel-Aal, G. (2003). 'MUCOADHESIVE VAGINAL TABLETS OF NATAMYCIN FOR VAGINAL CANDIDIASIS', Bulletin of Pharmaceutical Sciences Assiut University, 26(1), pp. 29-40. doi: 10.21608/bfsa.2003.65465
VANCOUVER
El-Gindy, G., El-Sayed, A., Mohame, S., Abdel-Aal, G. MUCOADHESIVE VAGINAL TABLETS OF NATAMYCIN FOR VAGINAL CANDIDIASIS. Bulletin of Pharmaceutical Sciences Assiut University, 2003; 26(1): 29-40. doi: 10.21608/bfsa.2003.65465
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