EVALUATION OF THE EFFECT OF POLYVINYLPYRROLIDONE AND CERTAIN ENHANCERS ON THE PERMEATION OF CORTICOSTERONE FROM TRANSDERMAL DELIVERY SYSTEMS: (PART II)
The purpose of the present study was to evaluate the permeation profiles of unlabeled corticosterone (CS) drug from gels and adhesive patches as transdermal delivery systems. The effect of polyvinylpyrrolidone and certain chemical enhancers octylpyrrolidone (OP) and dodecylpyrrolidone (DDP) on the flux of drug through hairless mouse skin was also studied. The results show that presence of solubilizing agents such as hydroxypropyl–beta-cyclodextrin (HP- -CD) decreased the drug flux from hydroxypropyl methylcellulose (HPMC) gel dermal base and controlled the diffusion kinetics. Increasing the drug thermodynamic activity by its autoclaving with 0.25% polyvinylpyrrolidone (PVP) (supersaturation) improved the drug flux through the skin by 3 fold from HPMC gel base dermal preparations. The results also reveal that chemical enhancer/HP- -CD mixtures represent a suitable combination for controlling the release as well as increasing the flux of drug through skin. The addition of 5% HP- -CD to OP solution not only increased the drug flux but also showed a controlled release that approached the zero order. Use of the chemical enhancer DDP in presence of HP- -CD shows a 10-fold increase in CS flux from HPMC gel base. The results of transdermal patches show that increasing the concentration of OP increased the cumulative amounts of Labeled corticosterone (3H-CS) permeated through the skin from two adhesives patches Duro-tak 2516 and 2287. There is a difference between the two adhesives patches in terms of skin permeation. The rate of drug permeated from the Duro-tak 2516 patch is 2 times greater than Duro-tak 2287, where there permeability coefficient is 9.05 and 4.67 x 10–9 respectively.
Hashem, F., Ghanem, A., El-leithy, E., & Shaker, D. (2003). EVALUATION OF THE EFFECT OF POLYVINYLPYRROLIDONE AND CERTAIN ENHANCERS ON THE PERMEATION OF CORTICOSTERONE FROM TRANSDERMAL DELIVERY SYSTEMS: (PART II). Bulletin of Pharmaceutical Sciences Assiut University, 26(2), 145-151. doi: 10.21608/bfsa.2003.65480
MLA
Fahima M. Hashem; Abdel Halim Ghanem; Eman S. El-leithy; Dalia S. Shaker. "EVALUATION OF THE EFFECT OF POLYVINYLPYRROLIDONE AND CERTAIN ENHANCERS ON THE PERMEATION OF CORTICOSTERONE FROM TRANSDERMAL DELIVERY SYSTEMS: (PART II)", Bulletin of Pharmaceutical Sciences Assiut University, 26, 2, 2003, 145-151. doi: 10.21608/bfsa.2003.65480
HARVARD
Hashem, F., Ghanem, A., El-leithy, E., Shaker, D. (2003). 'EVALUATION OF THE EFFECT OF POLYVINYLPYRROLIDONE AND CERTAIN ENHANCERS ON THE PERMEATION OF CORTICOSTERONE FROM TRANSDERMAL DELIVERY SYSTEMS: (PART II)', Bulletin of Pharmaceutical Sciences Assiut University, 26(2), pp. 145-151. doi: 10.21608/bfsa.2003.65480
VANCOUVER
Hashem, F., Ghanem, A., El-leithy, E., Shaker, D. EVALUATION OF THE EFFECT OF POLYVINYLPYRROLIDONE AND CERTAIN ENHANCERS ON THE PERMEATION OF CORTICOSTERONE FROM TRANSDERMAL DELIVERY SYSTEMS: (PART II). Bulletin of Pharmaceutical Sciences Assiut University, 2003; 26(2): 145-151. doi: 10.21608/bfsa.2003.65480
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