The present work reports on the synthesis and preliminary pharmacol. investigation of new 3-aryl-6,7-dimethyl-9-substituted thiazolo[3,2-a]benzimidazolium salts. These derivs. were synthesized by reacting the 3-aryl-6,7-dimethylthiazolo[3,2-a]benzimidazoles with the appropriate quaternizing agent. The latter compds. were, in turn prepd. by cyclodehydration of 5,6-dimethyl-2-(phenacylthio)benzimidazoles in polyphosphoric acid (PPA). The latter derivs. were obtained by the reaction of 5,6-dimethylbenzimidazole-2-thione with the appropriate phenacyl bromide. Some of the tested compds. have shown a pronounced hypoglycemic activity. The results do permit the assignment of compds. having N9-phenacyl entity as promising antidiabetic agents.
El-Shorbagi, A., Hayallah, A., Omar, N., & Ahmed, A. (2001). Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic. Bulletin of Pharmaceutical Sciences Assiut University, 24(1), 7-20. doi: 10.21608/bfsa.2001.65750
MLA
A. A. El-Shorbagi; A. A. Hayallah; N. M. Omar; A. N. Ahmed. "Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic". Bulletin of Pharmaceutical Sciences Assiut University, 24, 1, 2001, 7-20. doi: 10.21608/bfsa.2001.65750
HARVARD
El-Shorbagi, A., Hayallah, A., Omar, N., Ahmed, A. (2001). 'Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic', Bulletin of Pharmaceutical Sciences Assiut University, 24(1), pp. 7-20. doi: 10.21608/bfsa.2001.65750
VANCOUVER
El-Shorbagi, A., Hayallah, A., Omar, N., Ahmed, A. Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic. Bulletin of Pharmaceutical Sciences Assiut University, 2001; 24(1): 7-20. doi: 10.21608/bfsa.2001.65750
)
View on SCiNiTO