Five compounds (1-5) were firstly reported from the genus Centaurium family Gentianaceae. They were identified as Lisianthoside 1, Secoxyloganin 2, Secologanin dimethyl acetal 3, 1,8-Dihydroxy-3,5,6,7-tetramethoxyxanthone (Demethyleustomin) 4 and 1-Hydroxy3,5,6,7,8-pentamethoxyxanthone (Eustomin) 5. Structure elucidation was carried out with support of chemical and spectral analysis including 1D and 2D NMR experiments. All the isolated compounds showed promising antioxidant activity, liver microsomal enzymes reducing activity and CYP3A4 mRNA inhibition activity in the HepG2 cell line.
Allam, A., El-Shanawany, M., Backheet, E., & Nafady, A. (2014). PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES. Bulletin of Pharmaceutical Sciences Assiut University, 37(2), 65-76. doi: 10.21608/bfsa.2014.65789
MLA
Ahmed E. Allam; Mohamed A. El-Shanawany; Enaam Y. Backheet; Alaa M. Nafady. "PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES", Bulletin of Pharmaceutical Sciences Assiut University, 37, 2, 2014, 65-76. doi: 10.21608/bfsa.2014.65789
HARVARD
Allam, A., El-Shanawany, M., Backheet, E., Nafady, A. (2014). 'PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES', Bulletin of Pharmaceutical Sciences Assiut University, 37(2), pp. 65-76. doi: 10.21608/bfsa.2014.65789
VANCOUVER
Allam, A., El-Shanawany, M., Backheet, E., Nafady, A. PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES. Bulletin of Pharmaceutical Sciences Assiut University, 2014; 37(2): 65-76. doi: 10.21608/bfsa.2014.65789
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