Granule stress relaxation studies as a function of different lubricants

Ebba, F. E.; Prinderre, P.; Omar, S.; Piccerelle, Ph.; Opota, D. O.; Reynier, J. P.; Joachim, J.

doi:10.21608/bfsa.2001.65904

Granule stress relaxation studies as a function of different lubricants

Document Type : Original Article

Authors

¹ Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France

² Department of Pharmaceutics, Faculty of Pharmacy, He/wan University, Cairo, Egypt

10.21608/bfsa.2001.65904

Abstract

Effect of the visco-elastic properties of different lubricants, namely magnesium stearate, talc and precirol, on granule compaction properties was examd. using texture analyzer TAXT21. Stress relaxation curves of the compacts have been discussed in relation with three parameters (porosity, visco-elasticity as well as particle size). The study revealed that bonding in compacted granules lubricated with magnesium stearate was higher than those in compacts with other lubricants in study. It is reasonable that, the large stress relaxation due to magnesium stearate was plastic deformation dependent with no evidence of fragmentation. While, small stress relaxation due to talc or precirol suggested that, these materials deformed principally by fragmentation. However, magnesium stearate as tablet lubricant, could be characterized by minimizing the accumulation of stress in the compact, which cause problem of capping, leading to the optimization of tablet manufg.