A convenient and sensitive spectrofluorimetric method for the detn. of 6 dibenzazepine drugs: imipramine-HCl, desipramine-HCl, clomipramine-HCl, trimipramine maleate, opipramol-2HCl and carbamazepine was developed. The method depends on the oxidn. of the compds. with potassium dichromate in acid medium. The relative fluorescence intensities for all 6 drugs were measured at an excitation wavelength range of 350-360 nm and an emission wavelength range of 460-485 nm against a reagent blank prepd. similarly. The drugs could be detd. successfully in the concn. range of 0.1-3.0 μg/mL. The method was satisfactorily applied to their detn. in pharmaceutical prepns. and in spiked plasma samples. The results were in good agreement with those from official methods.
Mohamed, H., & Refaat, I. (1999). Spectrofluorimetric determination of some dibenzazepine drugs. Bulletin of Pharmaceutical Sciences Assiut University, 22(2), 191-196. doi: 10.21608/bfsa.1999.66121
MLA
Horria A. Mohamed; Ibrahim H. Refaat. "Spectrofluorimetric determination of some dibenzazepine drugs". Bulletin of Pharmaceutical Sciences Assiut University, 22, 2, 1999, 191-196. doi: 10.21608/bfsa.1999.66121
HARVARD
Mohamed, H., Refaat, I. (1999). 'Spectrofluorimetric determination of some dibenzazepine drugs', Bulletin of Pharmaceutical Sciences Assiut University, 22(2), pp. 191-196. doi: 10.21608/bfsa.1999.66121
VANCOUVER
Mohamed, H., Refaat, I. Spectrofluorimetric determination of some dibenzazepine drugs. Bulletin of Pharmaceutical Sciences Assiut University, 1999; 22(2): 191-196. doi: 10.21608/bfsa.1999.66121