L-Glutamine and glutamic acid were incorporated in a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton contg. different alkyl, cycloalkyl and aralkyl groups at N3 of the ring system. These THTT derivs. revealed high lipophilicity compared with L-glutamine and glutamic acid. The degrdn. kinetics were studied -in vitro- using aq. buffer solns. of pH values: 1.2, 6.0, 7.4, 7.8 and 9.0 at 37°. From the pH profile, the degrdn. was accounted for, in terms of specific base-catalyzed reactions. All of the compds. however, showed higher acid-stability.
El-Shorbagi, A. (2000). Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid. Bulletin of Pharmaceutical Sciences Assiut University, 23(1), 31-38. doi: 10.21608/bfsa.2000.66128
MLA
A. El-Shorbagi. "Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid". Bulletin of Pharmaceutical Sciences Assiut University, 23, 1, 2000, 31-38. doi: 10.21608/bfsa.2000.66128
HARVARD
El-Shorbagi, A. (2000). 'Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid', Bulletin of Pharmaceutical Sciences Assiut University, 23(1), pp. 31-38. doi: 10.21608/bfsa.2000.66128
VANCOUVER
El-Shorbagi, A. Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid. Bulletin of Pharmaceutical Sciences Assiut University, 2000; 23(1): 31-38. doi: 10.21608/bfsa.2000.66128
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