PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS

Document Type : Original Article

Authors

1 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida, USA

Abstract

Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compounds (P) were synthesized. A spectrofluorimetric method was used to test their in vitro monoamine oxidase inhibition. The compounds showed reasonable activities by the test performed. 

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