INVESTIGATION OF CONTROLLED RELEASE SOLID DISPERSION OF NAPROXEN USING EUDRAGIT RS AND RL POLYMERS

Abd El-Mohsen, Mohammed G.; Ismail, Ahmed

doi:10.21608/bfsa.1998.67985

INVESTIGATION OF CONTROLLED RELEASE SOLID DISPERSION OF NAPROXEN USING EUDRAGIT RS AND RL POLYMERS

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

² Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

10.21608/bfsa.1998.67985

Abstract

Naproxen was used as a model drug and Eudragit RS and RL were used as inert carriers in an attempt to study the controlled release solid dispersion. Naproxen solid dispersion was prepared using solvent evaporation technique. IR study illustrated Naproxen/Eudragits interaction. Dissolution-rate studies showed that the amounts of Naproxen released were found to be fitted to the Higuchi-Square root of time model. The study proved that the solid dispersions composed of Eudragit RS exhibited slow release rates when compared with those composed of Eudragit RL. By a simple modification in the polymeric ratio of both Eudragit RS and Eudragit RL, the kinetics of release can be modulated. A marked reduction in the magnitude of release rates was observed upon increasing the particle size. It was found that there was a linear relationship between the logarithmic value of release rate constant and the fraction of Eudragit RL in the coevaporate composed of Naproxen/RS/RL. The finding was a confirmatory indication that the release was following Higuchi-diffusion model. The study also proved that the compression forces had no effect on the release rate constant. The incorporation of polyvinylpyrrolidone in the coevaporates containing Eudragit RS improved and increased the release profile of Naproxen.