SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY

Document Type : Original Article

Authors

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

A series of 1-methyl-3-[N-(substituted benzalimino)carbamoyl] pyridinium iodide and their corresponding dihydropyridines were prepared by conventional methods. The prepared compounds were tested in vitro for their MAO inhibitory activity on liver mitochondria by kynuramine fluorimetric assay. The results showed that MAOI activity of quaternaries is more than the corresponding dihydro compounds.