FORMULATION AND EVALUATION OF CONTROLLED RELEASE IBUPROFEN TABLETS

Samy, Eman M.; Abdel Zaher, Ahmed O.; Abdel Maksoud, Safaa A.

doi:10.21608/bfsa.1996.68775

FORMULATION AND EVALUATION OF CONTROLLED RELEASE IBUPROFEN TABLETS

Document Type : Original Article

Authors

¹ Department of Industrial Pharmacy, Faculty of Pharmacy, Assuit University, Assiut, Egypt

² Department of Pharmacology, Faculty of Medicine, Assuit University, Assiut, Egypt

³ Department of Histology, Faculty of Medicine, Assuit University, Assiut, Egypt

10.21608/bfsa.1996.68775

Abstract

Controlled release ibuprofen tablets were prepared by coevaporation technique using Eudragit RSPM, ethylcellulose 20, Aerosil R972 and Aerosil 200 as carriers and Avicel pH102 as filler. The effect of different compression forces on the release rate of the drug was studied. The carriers used produce retardation in the release rate of ibuprofen in the following manner: Eudragit RSPM > ethylcellulose 20 > Aerosil R972 > Aerosil 200. The dependence of release rate (K) on hardness (H) may be approximated by the equation, Ln K = a H + b. The release mechanism follows zero order kinetic.
The antiinflammatory activity of the coevaporates was studied in albino rats using trypan-blue method. The coevaporates were also tested in albino mice for their analgesic activity using hot plate and p-benzoquinone induced writhing methods. The obtained results revealed that Eudragit RSPM and Aerosil 200 were the most effective in sustaining the antiinflammatory and analgesic actions of ibuprofen, while ethylcellulose 20 was the least effective. Histological examination of rat's stomach proved the efficiency of the tested coevaporates in inhibiting the ulcerogenic effects caused by the plain drug.