The synthesis of a number of chalcones derived from acetylpyridines and some p-substituted benzaldehydes has been accomplished. These compounds were evaluated for their alkylating activity by kinetic studies of their reaction with 2-mercaptoethanol. Compounds with electron withdrawing groups in the p-position of benzylidine moiety showed higher activities than compounds with electron donating groups. Quaternization of the pyridine ring decreased activity profoundly.
El-Koussi, N. (1995). KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES. Bulletin of Pharmaceutical Sciences Assiut University, 18(1), 49-53. doi: 10.21608/bfsa.1995.69679
MLA
N. A. El-Koussi. "KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES". Bulletin of Pharmaceutical Sciences Assiut University, 18, 1, 1995, 49-53. doi: 10.21608/bfsa.1995.69679
HARVARD
El-Koussi, N. (1995). 'KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES', Bulletin of Pharmaceutical Sciences Assiut University, 18(1), pp. 49-53. doi: 10.21608/bfsa.1995.69679
VANCOUVER
El-Koussi, N. KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES. Bulletin of Pharmaceutical Sciences Assiut University, 1995; 18(1): 49-53. doi: 10.21608/bfsa.1995.69679
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